2017年5月31日星期三

Clonazolam


Clonazolam (also known as clonitrazolam) is a benzodiazepine that has been sold online as a designer drug.
The synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested.
Clonazolam is reputed to be highly potent, and concerns have been raised that clonazolam and flubromazolam in particular may pose comparatively higher risks than other designer benzodiazepines, due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.5 mg.

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Methyldienedione




Basic Info
CAS: 5173-46-6
Customized: Customized
Suitable for: Elderly, Adult
Purity: >99%
Formula Weight: 270.37
Payment: T/T, Western Union and Money Gram
Express: EMS, DHL, FedEx, etc(Door-to-Door)
Origin: China
Powder: Yes
Certification: GMP, HSE, ISO 9001, USP, BP
Molecular Formula: C18h22o2
Appearance: White Powder
Delivery: Within 24hours After Your Payment


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Ibutamoren


Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.
Mk-677 COA:

TEST
ACCEPTANCE CRITERLA
RESULTS

TLC
Positive
Identification
UV spectrum
Positive

IR spectrum
Positive
Characteristics
White to yellowish-white crystalline powder
conform
Melting point
32 ~ 37ºC
33~36ºC
Specific optical rotation
+77°~+82°
+79.3°
Loss on drying
≤0.5%
0.15%
Assay
97 ~ 103%
99.08%
Free heptanoic acid
≤0.2 %
0.10%
Related substances
≤2%
Pass

Acetone ≤100ppm
Pass
Residual solvents(GC)
Methanol ≤100ppm
Pass

Pyridine ≤100ppm
Pass

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2017年5月26日星期五

Gonadotropin-releasing hormone



Gonadotropin-releasing hormone (GnRH) also known as gonadoliberin, and by various other names in its endogenous form and as gonadorelin (INN) in its pharmaceutical form, is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

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Sustanon




Sustanon is a trade name owned by Organon Pharmaceuticals for oil-based injectable blends of esterized testosterone compounds.

Sustanon 250 is a blend of four esterized testosterone compounds:

30 mg testosterone propionate
60 mg testosterone phenylpropionate
60 mg testosterone isocaproate
100 mg testosterone decanoate
Sustanon 100 was similar, though with three esters. This smaller dose was usually for pediatric use.

20 mg testosterone propionate
40 mg testosterone phenylpropionate
40 mg testosterone isocaproate
Sustanon 100 has not been produced since 2009.

TEST ITEMS
SPECIFICATION
RESULTS
Description
: White or Almost White Crystalline Powder
Solubility
: Practically insoluble in water, freely soluble in acetone

and in alcohol, soluble in fatty oils.
Identification
: IR
Positive
Assay(on dry bsis)
: 97.0~103.0%
98.57%
Specific Rotation
: +84°~+90°
+85.9°
Loss On Drying
: 0.5%max
0.31%
Related Substances
: Any impurity: 0.5%max
<0.5%

Total: 1.0%max
<1.0%
 
Disregard limit: 0.05%max
<0.05%



Conclusion
The specification conform with BP2005 standard

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Metenolone enanthate


Metenolone enanthate, or methenolone enanthate, is a dihydrotestosterone (DHT)-based anabolic-androgenic steroid (AAS). It is an ester derivative of metenolone sold commonly under the brand name Primobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens. It is used by people who are very susceptible to estrogenic side effects, having lower estrogenic properties than nandrolone. Metenolone, in form of enanthate and acetate (see metenolone acetate), is available as an injection or as an oral formulation, respectively. The injection is regarded as having a higher bioavailability. It is an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Metenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. 

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2017年5月25日星期四

Boldenone


Boldenone (INN, BAN) (brand names Equipoise, Ganabol, Equigan, Ultragan, Boldane), also known as Δ1-testosterone, 1-dehydrotestosterone, or androsta-1,4-diene-3-one-17β-ol, is a synthetic anabolic-androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone. It is often formulated as boldenone undecylenate, the undecylenate ester.

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Betamethasone


Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others. It can be taken by mouth, injected into a muscle, or applied as a cream.
COA:
ITEMSSPECIFICATIONSRESULTS
Appearance
A white to almost white,odorless, crystalline powder
 Conforms
IdentificationComplies with the stanard  Conforms
Loss on drying≤0.5%0.08 %
Residue on Ignition≤0.3%0.3%
Specific on rotation+118~ +126.+ 123.4 °
Melting point50 ℃ ~ 60 ℃50 ℃ ~ 60 ℃
Sulphate ash≤0.1%0.05%
Heavy metals≤ 20 ppm< 20ppm
Related substance
Total impurity ≤2.0%
Single impurity ≤.0%
0.41%
0.12%
Methanol≤ 3000 ppmConforms
Ethylacetate≤ 3000 ppmConforms
DMF≤ 3000 ppmConforms
Acetone≤ 3000 ppmConforms
Dichlormethane≤ 3000 ppmConforms
Assay97.0~103.0%100.0 %
ConclusiionThis product complied with the standard of EP 6.

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Benzocaine


Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.
Chemical properties

Benzocaine COA:

ProductBenzocaine
CAS No.94-09-7Packing25 kg/drum
Man.date2016-06-02Expiry date2018-06-01
StandardUSP 36
ItemsSpecificationsResults
AppearanceWhite crystalline powderWhite crystalline powder
IdentificationConsistent with the standard chartConformed
Reactive IdentificationOrange RedOrange Red
Melting Point88ºC ~ 92ºC89.3ºC ~ 90.3ºC
Loss on Drying≤0.5%0.3%
Easy CarbideComply with USP standardConformed
Residue on ignition≤0.1%Conformed
Heavy Metals≤10ppmConformed
Assay98% ~ 102%101.4%
Particle size90% pass 40 meshConformed
ConclusionQualified

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RAD140




Description:
RAD140, from its internal nonsteroidal selective androgen receptor modulator ("SARM") discovery program, for full preclinical development as a potential therapy for the treatment of age-related muscle loss (sarcopenia) and other musculoskeletal conditions such as osteoporosis. Radius selected RAD140 from a series of promising SARMs after it demonstrated exceptional selectivity for anabolic activity in well- validated in vivo models.
Radius expects to complete formal toxicology studies that will allowed.
This makes its usage significantly safer and more effective compared to traditional prohormones and anabolic steroids.
According to the Cambridgebased pharmaceuticals company Radius, the potent, orally bioavailable and nonsteroidal RAD 140 SARM is designed to make the hormonal receptors in the tissues of the body act the same way as if they're getting a good dose of testosterone, setting off the same effects as if you're cycling with prohormones and anabolic steroids minus unwanted side effects.
Moreover, clinical studies also show that RAD 140 SARM also has a few other benefits, which we will discuss more thoroughly in a moment.
Rad-140 Oral SARMs Steroids For Massive Muscle Gain 118237-47-0 Pharma Grade Steroids
COA
ItemSpecificationResult
Appearancewhite powderpass
Identificaton
The retention time of the major peak is
confirm to the RS
pass
Loss on DryingNot more than 0.5%0.33%
Assay(HPLC)Not less than 99.0%99.59%
Ignition residueNot more than 0.1%pass
Heavy metalNot more than 20 ppmpass

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Enobosarm



Enobosarm, also known as ostarine, is an investigational selective androgen receptor modulator (SARM) from GTX, Inc for treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merck & Company.

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2017年5月24日星期三

Lorcaserin


Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.
Medical uses

Lorcaserin is used long term for weight loss in those who are obese.

Product nameLORCASERIN
CAS NO.616202-92-7
SynonymsLORCASERIN;(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;Apd   356;Apd356;Apd-356;Ar-10a;Unii-637E494o0z;(1R)-8-Chloro-2,3,4,5-tetrahydro-1-Methyl-1H-3-benzazepine
MFC11H14ClN
bp288 ºC
density1.075
Fp128 ºC
storage temp.-20 ºC Freezer
Appearance:  Colorless to yellow liquid
Purity: more than 98.0%
Usage:  Pharmaceutical intermediates

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2017年5月23日星期二

5-Methylcytosine


5-Methylcytosine is a methylated form of the DNA base cytosine that may be involved in the regulation of gene transcription. When cytosine is methylated, the DNA maintains the same sequence, but the expression of methylated genes can be altered (the study of this is part of the field of epigenetics). 5-Methylcytosine is incorporated in the nucleoside 5-methylcytidine.

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2017年5月22日星期一

4'-Methyl-α-pyrrolidinohexiophenone




4'-Methyl-α-pyrrolidinohexiophenone or MPHP is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring.

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4'-Methyl-α-pyrrolidinobutiophenone




4'-Methyl-α-pyrrolidinobutiophenone or MPBP is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-shortened homologue.

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Dimethocaine (Larocaine)




Dimethocaine (Larocaine) is a local anesthetic with stimulant properties that some studies have shown to be half the potency of cocaine.

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Anti-ERK5



synthetic peptide corresponding to amino acids 789-802 of human ERK5.
General description
Extracellular signal-regulated kinase 5 (ERK5), also referred to as big-MAP kinase 1 or BMK1, is a protein that belongs to Mitogen-activated protein kinases family and is expressed mainly in skeletal muscle, kidney, heart and placenta. It has a critical role in different cellular processes like differentiation, proliferation and survival. Anti-ERK5 (big-MAPK, BMK1) antibody can be used to study the differential tissue expression and intracellular localization of the MAP Kinase isoform in normal and neoplastic tissues. Rabbit anti-ERK5 (big-MAPK, BMK1) antibody reacts specifically with ERK5 (97 kD) from mouse fibroblast cell extract.

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2017年5月19日星期五

5-Methyl-MDA


5-Methyl-3,4-methylenedioxyamphetamine (5-Methyl-MDA) is an entactogen and psychedelic designer drug of the amphetamine class. It is a ring-methylated homologue of MDA and a structural isomer of MDMA.

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