Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Under the trade name Robaxin, it is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. The mechanism of action of methocarbamol is currently unknown, but may involve the inhibition of carbonic anhydrase. The muscle relaxant effects of methocarbamol are largely attributed to central depressant effects; however, peripheral effects of methocarbamol to prolong muscle refractory period have also been reported.
Metabolism
Methocarbamol is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is not hydrolyzed metabolically; metabolism is by Phase I ring hydroxylation and O-demethylation, followed by Phase II conjugation. All the major metabolites are unhydrolyzed carbamates.
Product name: Methocarbamol
Synonyms: guaiacol glyceryl ether carbamate; 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
CAS RN.: 532-03-6
EINECS: 208-524-3
Molecular Weight: 241.2405
Molecular formula: C11H15NO5
InChI=1/C11H15NO5/c12-11(15)17-10-4-2-1-3-9(10)16-6-5-8(14)7-13/h1-4,8,13-14H,5-7H2,(H2,12,15)
Refractive index: 1.57
Hazard Symbols: Xn:Harmful
Risk Codes: R22;R42/43;
Safety Description: S36
Apperance : white powder
Means of Transportation: By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)
Usage : chemical research
Storage: Store in dry, dark and ventilated place
Package: Barrel or Customize
| Item | Standard | Test Results | |
| Identification | A.H-NMR:Comply with the structure | Complies | |
| B.LC-MS:Comply with the structure | Complies | ||
| C.The IR spectrum of sample should be identical with that of reference standard; | Complies | ||
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
| Complies | ||
| Crystallinity | meets the requirements. | Complies | |
| Loss on drying | ≤2.0% | 0.19% | |
| Heavy metals | ≤10 ppm | <10ppm | |
| Water | ≤1.0% | 0.1% | |
| Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.009% | |
| Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
| Total Impurity | ≤0.5% | 0.18% | |
| Purity | ≥99.0% | 99.7% | |
| Assay | 99.0%~101.0% (anhydrous substance). | 99.8% | |
| Microbiological Analysis | |||
| Total plate count | ≤1000cfu/g | Complies | |
| Yeast and Moulds | ≤100cfu/g | Complies | |
| E. Coli. | Absent | Negative | |
| Salmonella | Absent | Negative | |
| S.aureus | Absent | Negative | |
| Storage | Preserve in well-closed, light-resistant and airtight containers. | Complie | |
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