Diethylstilbestrol (DES) (INN, USAN, BAN), also known formerly (and inappropriately) as stilboestrol (BAN), is a synthetic, non-steroidal estrogen of the stilbestrol group that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.
In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed. The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons".
Medical uses
DES has been used in the past for the following indications:
Recurrent miscarriage in pregnancy
Hormone replacement therapy for menopausal symptoms such as hot flashes and vaginal atrophy
Hormone replacement therapy for hypoestrogenism (e.g., gonadal dysgenesis, premature ovarian failure, and after oophorectomy)
Postpartum lactation suppression to prevent or reverse breast engorgement
Gonorrheal vaginitis (discontinued following the introduction of the antibiotic penicillin)
Prostate cancer and breast cancer
Prevention of tall stature in tall adolescent girls
As an emergency postcoital contraceptive
Court sanctioned Chemical castration for men convicted of sex-related crimes
Product Description:
Other name: (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene;(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol;DES
CAS NO.: 56-53-1
MF: C18H20O2
MW: 268.35
EINECS NO.: 200-278-5
InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3
Density:1.107g/cm3
Melting Point:169-175 ºC
Boiling Point:407.1°Cat760mmHg
Flash Point:186.9°C
Appearance: white crystalline or powder
Assay:99%min
Analysis Certificate
Specification:
| Items | Specification | Results |
| Appearance | the colorless crystal or white crystal powder | almost white crystalline powder |
| Identification | 1) positive reaction | complies |
| 2) the main peak retention time of test solution should comply with working standard | complies | |
| 3) IR spectrum conform to the reference | complies | |
| Acid basicity | neutrality is reacted | complies |
| Melting point | 169-172oC | 169-170oC |
| Loss on drying | ≤0.5% | 0.2% |
| Organic volatile impurities | conform | complies |
| Sulphated ash | ≤0.1% | 0.04% |
| Assay (C18H20O2) | 97-103% | 99% |
Packaging & Shipping
Packaging
1.1kg/Aluminum foil bag; 25 kg card board drum; 1G 50G 25kg/Drum or customized requirement.
2.According to the clients requirements.
3.Drum&plastic bags, Aluninium foiled bag&zip lock bag
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