2017年3月8日星期三

ethyl apovincaminate

Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"), an extract from the lesser periwinkle plant. Vinpocetine was first isolated from the plant in 1975 by the Hungarian chemist Csaba Szántay. The mass production of the synthetic compound was started in 1978 by the Hungarian pharmaceutical company Richter Gedeon.

Vinpocetine is not FDA approved in the United States for therapeutic use. The U.S. Food & Drug Administration (FDA) has ruled that vinpocetine, due to its synthetic nature and proposed therapeutic uses, was ineligible to be marketed as dietary supplement under the Federal Food, Drug, and Cosmetic Act (FDCA).

Vinpocetine has been reported to have cerebral blood-flow enhancing and neuroprotective effects, and has been used as a drug in Eastern Europe for the treatment of cerebrovascular disorders and age-related memory impairment.

Name: Vinpocetine
CAS: 42971-09-5
Quality Standard: USP/BP/EP/JP
Apperance: White crystalline power

Specification
Items
Requirements
Results
Appearance
W  White or slightly yellow, crystalline powder.
Complies 
Solubility
Practically insoluble in water, soluble in methylene 
chl  chloride, slightly soluble in anhydrous ethanol
Complies 
Identification


  1. A. Specific optical ration
Should be positive
Complies 
  1. B. Infrared absorption
Should be positive
Complies 
  1. C. HPLC
The retention time of the main peak of the sample 
solution corresponds to that of the principal peak 
for the stock standard solution, as obtained in the 
test for organic impurities 
Complies 
Test


  1. A. Specific optical ration
+ 127 ° to + 134°(dried substance)
+ 132.4°
  1. B. Related substances
Impurity A≤0.6%
Impurity B≤0.5%
Impurity C≤0.3%
Impurity D≤0.5%
Any other impurities≤0.1%
Total impurities ≤1.0%
0.06%
0.30%
0.06%
NA
0.06%
0.48%
  1. C. Loss on drying
≤ 0.5%
0.19%
  1. D. Sulphated ash
≤ 0.1%
0.05% 
  1. E. Heavy metals
NMT10ppm
Complies 
Assay 
98.5%~101.5%
99.4%

Conclusion
The product conforms to EP7
PACKING & SHIPING

Delivery time:In 3-5 days
Shipping methods:By Courier, by air or by sea
Packaging: 1kg, 5kg ,25kg or as requested



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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body


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