Trimetazidine is a drug for angina pectoris sold under the brand name Vastarel MR. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of fatty acid metabolism, also known as fatty acid oxidation inhibitor.
Medical uses
Trimetazidine is usually prescribed as a long-term treatment of angina pectoris, and in some countries (including France) for tinnitus and dizziness. It is taken twice a day. In 2012 European Medicines Agency (EMA) finished a review of benefits and risks of trimetazidine and recommended restricting use of trimetazidine-containing medicines just as an additional treatment of angina pectoris in case of inadequate control by or intolerance to first-line antianginal therapies.
Controlled studies in angina patients have shown that trimetazidine increases coronary flow reserve, thereby delaying the onset of ischemia associated with exercise, limits rapid swings in blood pressure without any significant variations in heart rate, significantly decreases the frequency of angina attacks, and leads to a significant decrease in the use of nitrates.
It improves left ventricular function in diabetic patients with coronary heart disease. Recently, it has been shown to be effective in patients with heart failure of different etiologies.
Product Description:
Other name: 1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine
CAS NO.: 5011-34-7
EINECS NO.: 225-690-2
MF: C14H22N2O3
MW: 266.34
InChI: 1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
Appearance:white fine powder
Specification: 99%
Standard: EP/BP/USP/CP
Analysis Certificate:
Specification:
| Item | Specification |
| Appearance Form | white powder |
| Residue on ignition | ≤0.1% |
| Assay | 98%min |
| Mesh | 80mesh |
| Loss on Drying | ≤0.5% |
| Total plate count | ≤1000cfu/g |
| Yeast & Mold | ≤100cfu/g |
| E.Coil | Negative |
| Salmonella |
Negative
|
Packaging & Shipping:
Packing: 25kg/drum or as your request.
Shelf Life: Two years when properly stored.
Delivery: within two weeks after receiving your prepayment.
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