Product Description:
Description: Sorafenib tosylate is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
Synonym: BAY 439006; BAY439006; BAY-439006; BAY 439006 Tosylate Salt; BAY 549085; Nexavar; SFN.
IUPAC/Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
SMILES Code: O=C(C1=NC=CC(OC2=CC=C(C=C2)NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=C1)NC
[English Name] Sorafenib tosylate
[Test Method]HPLC
[Purity]≥99%
[CAS No.] 284461-73-0
[Mol. Formula]C21H16ClF3N4O3
[Purity]> 99% by HPLC
[Packaging]1KG,10KG;25KG/DRUM...
Package and quantity according to customer's detail requirement
[Remark] In stock, customized for large scale.
Specifications:
Product Name
|
Sorafenib tosylate
| ||
Batch No.
|
14121501
|
Mfg. date
|
2014-12-15
|
Test Date
|
2014-12-25
|
Exp. date
|
2016-12-14
|
Tests
|
Specifications
|
Results
| |
Description
|
White to yellowish powder, very hygroscopic.
|
Off-white powder, very hygroscopic.
| |
Solubility
|
Freetly soluble In water and methanol and dichloromethane
|
Complies
| |
Identification
| (1)By IR, To match with working standard |
Complies
| |
| (2)It gives reaction of sodium |
Complies
| ||
Impurities A
|
≤0.1%
|
Not detected
| |
Related compounds
|
Any impurity ≤0.1%
|
<0.1%
| |
Total impurities ≤0.4%
|
0.25%
| ||
Residual Solvents
|
Acetidin≤ 0.5%
|
Not detected
| |
Dichloromethane≤ 0.06%
|
Not detected
| ||
Methanol≤ 0.3%
|
Not detected
| ||
Acetone ≤ 0.5%
|
Not detected
| ||
Acetonitrile≤0.041%
|
Not detected
| ||
Ethanol≤0.5%
|
0.04%
| ||
N, N-dimethylformamide≤0.088%
|
Not detected
| ||
Water
|
≤ 5.0%
|
1.38%
| |
Assay
|
99.0%-101.0%(On anhydrous basis)
|
99.98%
| |
Conclusion
|
Conform to EP8.0
| ||
Packaging & Shipping:
Package:
1kg,2kg,5kg/Aluminum Bag or small package as customer's requirement;
10kg,15kg,25kg/Drum,with food grade plastic bag inside.
Storage:
Store in a cool dry area.Keep Away from strong direct light.
Shipping:
By international express, air shipping, sea shipping.
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