2017年3月21日星期二

N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide


Dasatinib, previously known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral Bcr-Abl tyrosine kinase inhibitor (inhibits the "Philadelphia chromosome") and Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is being evaluated for use in numerous other cancers, including advanced prostate cancer.

Product Description:

English name: Dasatinib
Other name: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
CAS Number: 302962-49-8
Molecular Formula: C22H28ClN7O3S
Molecular Weight: 506.0208
InChI: 1/C22H26ClN7O2S.H2O/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31;/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27);1H2
Standard: USP/BP/CP/EP
Appearance: white crystalline powder

Specifications:
Spec.:Min 98% of Dasatinib
Test ItemsSpecificationResults
DescriptionWhite to off white crystalline powderComply
Melting point166-170°C167.3-168.1°C
IdentificationPositive reactionPositive reaction
Related substances≤1.0%0.16%
Loss on drying≤0.5%0.06%
Residue on ignition≤0.1%0.02%
Chloride≤0.014%<0.014
Heavy Metals≤20ppm<20ppm
Clarity of solutionConform to standardComplies
Microbial Limit≤20ppm<20ppm
Assay≥99.0%99.12%

Packaging & Shipping:
Package: By 25kgs/drum, inner by double plastic bag or as your request.
Storage Situation: Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Shelf Life: Two years when properly stored.
Delivery: within two weeks after receiving your prepayment.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

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