Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, and to relieve the discomfort of mouth sores. In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.
It is also known under the brand names Kenalog (topical) and Volon A as an injection, to treat allergies, arthritis, eye diseases, intestinal problems, and skin diseases. There are possible risks from an injection. It has been known to cause fat and muscle loss at an injection site, leaving a large divot bone deep.
Medical use
Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions. When applied as a topical ointment, applied to the skin, it is used to mitigate blistering from poison ivy, oak, and sumac,[citation needed]. When combined with Nystatin, it is used to treat skin infections with and discomfort from fungus, though it should not be used on the eyes, mouth, or genital area. It provides relatively immediate relief and is used before using oral prednisone. Oral and dental paste preparations are used for treating aphthous ulcers.
As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period.
Uncommonly, intramuscular injection of triamcinolone acetonide may be indicated for the control of severe or incapacitating allergic states for which conventional treatments have failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.
Product Name: Triamcinolone acetonide
Synonyms: KENALOG;ARISTODERM;9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE;9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE;9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE;9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE
CAS: 76-25-5
MF: C24H31FO6
MW: 434.5
EINECS: 200-948-7
Product Categories: Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;NASACORT
mp 274-278°C (dec.)
storage temp. Refrigerator
Merck 9596
Stability: Combustible. Incompatible with strong oxidizing agents.
Chemical Properties White Solid
Usage A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).
Usage antiinflammatory .
Speicification:
| Items | Specifications | Results |
| Characters | A white or almost white crystalline powder | Almost white crystalline powder |
| Identification | A: IR Absorption | Complies |
| B:TLC | Complies | |
| Specific optical rotation | Between +100°and +107° | +102° |
| Water | Not more than 2.0% | 1.30% |
| Related substances | Any infividual impurity not more than 0.25% | 0.18% |
| Total impurities not more than 0.5% | 0.30% | |
| Assay | Between 97.0%~103.0% | 100.60% |
| Particle size | ||
| 100%<15μm | 100%<15μm | |
| 99%<10μm | 99.0%<10μm | |
| 80%<5μm | 80.0%<5μm | |
| Conclusion | The results can conform with EP5 | |
USP34
| Items | Specifications | Results |
| Appearance | White or almost white crystalline powder | White crystalline powder |
| Identification | 1) Infrared Absorption | Compliance |
| 2) Ultraviolet Absorption | ||
| Specific Rotation | +118°~+130° | +121° |
| Loss on drying | ≤1.5% | 0.10% |
| Heavy metals | ≤0.0025% | Compliance |
| Chromatographic Purity | Any individual impurity ≤0.3% | Any dividual impurity: 0.08% |
| Total impurities≤0.8% | Total impurities: 0.4% | |
| Residual solvent | Methanol≤0.3% | 0.03% |
| Ethanol≤0.5% | 0.04% | |
| Acetone≤0.5% | Not detected | |
| Chloroform≤0.006% | 0.00% | |
| Assay | 97.0%~102.0%, calculated on the dried basis | 100.60% |
| Particle Size | D90=28.15μm | |
| Conclusion | The product conforms to USP34 | |
Packaging & Shipping
Packaging
[Storage] Stored in a clean, cool and dry area; keep away from strong, direct light.
[Shelf Life] 2 years when properly stored.
[Packing]
Inner double plastic bags--25kg/Fiber drum (35*35*53cm, GW: 28kg, NW: 25kg, 0.06CBM);
Inner double plastic bags--5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg);
Inner double plastic bags--1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
[Delivery] 5 working days after payment.
Shipping
1. Preferentially DHL or FedEx for quantity less than 50KG; Air shipping for 100KG above;
Sea shipping for quantity over 500KG.
2. For customers from Russia, Mexico, Turkey, Slovenia, Romania, etc, before placing an order,
please kindly confirm if you can make clearance when goods reach your customs.
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